• Yi Yang, Zhiheng Guo, Zhenpeng Wang, Lili Luo, and Ying Chen.
• Center of Reproductive Medicine and Center of Prenatal Diagnosis.
• Medicine (Baltimore). 2020 Jul 10; 99 (28): e21198.

IntroductionKasabach-Merritt Syndrome (KMS) is an extremely rare disease in adults, which lead to consumptive coagulopathy characterized by severe hypofibrinogenemia and thrombocytopenia. PATIENT CONCERNS:: a 25-year-old Chinese pregnant women complicated by preeclampsia and KMS presented with refractory postpartum hemorrhage and incision bleeding after cesarean section.DiagnosisThe diagnosis of KMS was made based on clinical manifestation of Kaposiform Hemangioendothelioma, severe hypofibrinogenemia and thrombocytopenia.InterventionsAfter a poor response to massive blood products transfusion for 1 week, corticosteroid treatment was initiated for 3 days.OutcomesThe patient reached a normal platelet count and a mild anemia within 4 weeks. Two months later, all laboratory values had returned to normal, and the incision was healing well.ConclusionPregnancy complicated by preeclampsia and surgery may have contributions for the development of Kasabach-Merritt syndrome. Corticosteroid is indicated in the episode of acute Kasabach-Merritt syndrome after the failure of massive blood transfusion.

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