• Turk J Med Sci · Feb 2019

    Association of common IL-10 promoter gene variants with the susceptibility to head and neck cancer in Tunisia

    • Lamia Maknı, Cherif Ben Hamda, Abrar Al-ansarı, Oussema Souıaı, Ezzedine Gazouanı, Amel Mezlını, Wassim Almawı, and Besma Yacoubı Loueslatı.
    • Turk J Med Sci. 2019 Feb 11; 49 (1): 123-128.

    Background/AimWe investigated the association of three IL-10 promoter single-nucleotide polymorphisms and altered IL-10 plasma levels with the risk of head and neck cancer (HNC).Materials And MethodsStudy subjects comprised 194 HNC patients [137 nasopharyngeal cancer (NPC) and 57 laryngeal cancer (LC)], and 263 healthy controls. Genotyping of rs1800896 (-1082A>G), rs1800871 (-819C>T), and rs1800872 (-592A>C) IL-10 variants was performed by real-time PCR; IL-10 levels were measured by enzyme amplified immuno sensitivity assay (EAISA).ResultsStudy subjects comprised 194 HNC patients [137 nasopharyngeal cancer (NPC) and 57 laryngeal cancer (LC)], and 263 healthy controls. Genotyping of rs1800896 (-1082A>G), rs1800871 (-819C>T), and rs1800872 (-592A>C) IL-10 variants was performed by real-time PCR; IL-10 levels were measured by enzyme amplified immuno sensitivity assay (EAISA).ConclusionOur results demonstrate that IL-10-1082, IL-10-819, and IL-10-592 variants, and haplotypes GC and GT constitute biomarkers for early detection of HNC, especially NPC subtype. IL-10 -819T/C and TA haplotype may be used as biomarkers for early detection of LC.

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