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- Gül Sema Keskin, Özant Helvacı, Çağrı Yayla, Özge Paşaoğlu, Çağlar Keskin, Turgay Arınsoy, and Ülver Derici.
- Turk J Med Sci. 2019 Feb 11; 49 (1): 139-146.
Background/AimWe aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease.Materials And MethodsTwenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery.YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = –0.674 and r = –0.471, respectively).This study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements
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