• Rabiye Altinbaş, Ayşe Barış, Sümeyye Şen, Recep Öztürk, and Nuri Kiraz.
• Department of Microbiology, Division of Mycology, Eskişehir City Hospital, Eskişehir, Turkey
• Turk J Med Sci. 2020 Dec 17; 50 (8): 202420312024-2031.

Background And AimInfections caused by Candida species are significantly increasing today, and invasive Candida infections are generally associated with high mortality. Early diagnosis and identification of Candida spp. is important for the determination of antifungal agents that will be used for treatment. The aim of the present study was to provide a better regimen for Candida infections in the future.Materials And MethodsTheSensititre YeastOne (SYO) method was compared with The Clinical Laboratory Standards Institute (CLSI) reference broth microdilution (BMD) testing method. Endpoints of minimal inhibitory concentrations (MICs) were determined for both methods.ResultsBy using both methods, MIC values of micafungin, caspofungin, voriconazole, and fluconazole were lower than amphotericin B. The values obtained with the SYO method were in high categorical agreement for ecinocandins and amphotericin B. The results of voriconazole and fluconazole were in low categorical agreement. The categorical agreement between the SYO and the BMD results at 24 h was 82.1% for VORI and 98.4% for AMB. Values obtained with SYO method for all antifungal agents were in high essential agreement with the data of the CLSI reference BMD method. The essential agreement between the SYO and the BMD results at 24 h was 94.0% for MFG and 99.0% for AMB.ConclusionsThe SYO method was ready-to use, so it appeared to be easier and more efficient for Candida isolates.This work is licensed under a Creative Commons Attribution 4.0 International License.

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