• Zeynep Turan and Murat Zinnuroğlu.
• Department of Physical Medicine and Rehabilitation, Koç University Hospital, İstanbul, Turkey
• Turk J Med Sci. 2020 Dec 17; 50 (8): 1983-1992.

Background/AimThis study aims to investigate peripheral nerve excitability in patients with subacute stroke.Materials And MethodsThestudy was performed in 29 stroke patients within the subacute period and 29 healthy controls using QTRAC software and TRONDNF protocol. The threshold electrotonus, recovery cycle, stimulus-response, strength-duration, and current-threshold relationships were recorded.ResultsThe membrane was more hyperpolarized, and excitability was decreased in the hemiplegic side. The impairment of inward rectifying channel function, degree of hyperpolarization, and decrease of excitability were directly related to the Brunnstrom stages, which were more pronounced in lower stages.ConclusionThe lower motor neurons were affected at the level of axonal channels as a result of upper motor neuron lesions. It can be due to dying back neuropathy, homeostasis, and neurovascular regulation changes in the axonal environment, activity-dependent plastic changes, loss of drive coming from the central nervous system, or a combination of these factors.This work is licensed under a Creative Commons Attribution 4.0 International License.

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