• Steven Hsu, Van-Khue Ton, M Dominique Ashen, Seth S Martin, Ty J Gluckman, Payal Kohli, Stephen D Sisson, Roger S Blumenthal, and Michael J Blaha.
• Ciccarone Center for the Prevention of Heart Disease, The Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. steven.hsu@jhmi.edu
• Clin Cardiol. 2013 Jul 1; 36 (7): 383-93.

AbstractAtherosclerotic cardiovascular disease (CVD) is the leading cause of death in the United States and worldwide. Fortunately, it is often preventable with early adoption of lifestyle modification, prevention of risk factor onset, and aggressive treatment of existing risk factors. The Million Hearts Initiative is an effort by the Centers for Disease Control that aims to prevent 1 million myocardial infarctions and strokes over the next 5 years. As part of this initiative, we present a simply organized "ABCDE" approach for guiding a consistent comprehensive approach to managing cardiovascular risk in daily clinical practice. ABCDE stands for assessment of risk, antiplatelet therapy, blood pressure management, cholesterol management, cigarette/tobacco cessation, diet and weight management, diabetes prevention and treatment, and exercise, interventions regularly used to reduce cardiovascular (CV) risk. Throughout this article we summarize recommendations related to each topic and reference landmark trials and data that support our approach. We believe that the ABCDE approach will be the core framework for addressing CV risk in our effort to prevent CVD. © 2013 Wiley Periodicals, Inc.

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