• Rachel O Coats, Kirsty L Crossley, Naomi Conlin, Jianhua Wu, Joanna M Zakrzewska, Sue H Pavitt, Nicholas Phillips, and Mark Mon-Williams.
• School of Psychology, University of Leeds, Leeds, LS2 9JT, UK. r.o.a.coats@leeds.ac.uk.
• J Headache Pain. 2020 Jul 17; 21 (1): 9191.

BackgroundTrigeminal neuralgia (TN) is an orofacial condition defined by reoccurring, spontaneous, short-lived but excruciating stabbing pain. Pharmacological interventions constitute the first-line treatment for TN, with antiepileptic drugs commonly prescribed. People treated for TN pain with antiepileptic drugs describe cognitive and motor difficulties affecting activities of daily living, and report poorer quality of life. We undertook the first comprehensive objective evaluation of sensorimotor and cognitive performance in participants being treated for TN pain with antiepileptic drugs relative to age-matched controls.MethodsParticipants (43 TN, 41 control) completed a battery of sensorimotor (steering, aiming and tracking) and cognitive (working memory, processing speed, inhibition) tasks.ResultsThe TN group performed significantly worse than controls on the sensorimotor tracking and aiming tasks and across all cognitive measures.ConclusionsThe data explain why patients treated with antiepileptic drugs report impairment when conducting activities of daily living (given the need for cognitive and motor capability within most of these). The study is an important first step in: (i) ensuring there is adequate information on the impact of pharmacological treatment; (ii) identifying measures to determine optimal medication dosage and track change over time; (iii) creating an evidence base that could allow scientific justification of alternative pain treatment options for TN (e.g. the costs/benefits of surgery).

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