• Somayeh Ramesh, Mohammad Ali Besharat, and Hossein Nough.
• Department of Psychology, University of Tehran, Tehran, Iran.
• Arch Iran Med. 2020 Mar 1; 23 (3): 175-180.

BackgroundBiological and psychological factors contribute to cardiovascular disease (CVD). This study aimed to test the moderating effect of social loneliness in the relationship between worry and anger rumination, and CVD severity.MethodsA total of 327 patients with CVD (138 women, 189 men) participated in this study. The Penn State Worry Questionnaire (PSWQ), Anger Rumination Scale (ARS), Social Loneliness Scale (SLS), and Gensini score as an indicator of CVD severity were used to collect data. Data were analyzed using Pearson correlation and stepwise regression.ResultsThe results of this study showed a significant positive correlation between worry (54.44 ± 12.31, r = 0.59, P < 0.01), anger rumination (46.54 ± 12.47; r = 0.36; P < 0.01), and social loneliness (28.22 ± 9.13, r = 0.65, P < 0.01) with CVD severity (15.07 ± 5.13). In other words, higher levels of worry, anger rumination, and social loneliness are associated with exacerbation of CVD. Social loneliness was a moderator in the relationship between worry and CVD severity (ΔR2 = 0.007, F= 4.2870, P < 0.05), suggesting the importance of worry in CVD severity, especially in lonely people. The main effects of worry and social loneliness on CVD severity were β = 0.32, SE = 0.04, 95% CI = 0.2289, 0.4222, P < 0.001 and β = 0.46, SE = 0.04, 95% CI = 0.3649, 0.5572, P < 0.001, respectively. The moderating effect of social loneliness on the relationship between worry and CVD severity was β = 0.07; SE = 0.03; 95% CI = 0.0074, 0.1522; P < 0.001. Social loneliness was not a moderator in the relationship between anger rumination and CVD severity (ΔR2 = 0.006, F = 3.10, P > 0.05).ConclusionBased on the findings of this research, it can be concluded that along with biological factors, attention to the role of psychological factors of worry, anger rumination, and loneliness in preventive and therapeutic interventions related to CVD is a special necessity.© 2020 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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