• Singap Med J · Oct 2019

    Endoscopic submucosal dissection of colorectal neoplasms: an audit of its safety and efficacy in a single tertiary centre in Singapore.

    • James Weiquan Li, Tiing Leong Ang, Wang Lai Mun LM Department of Laboratory Medicine, Changi General Hospital, Singapore., Andrew Boon Eu Kwek, Malcolm Teck Kiang Tan, Kwong Ming Fock, and Eng Kiong Teo.
    • Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore.
    • Singap Med J. 2019 Oct 1; 60 (10): 526-531.

    IntroductionEndoscopic submucosal dissection (ESD) provides a higher en bloc and R0 resection rate than endoscopic mucosal resection. Colorectal ESD is not widely used because of its technical difficulty and risk of complications, especially for right-sided colonic lesions. We audited the clinical outcomes of our initial experience with colorectal ESD.MethodsWe reviewed data collected from a prospective registry of patients who underwent colorectal ESD from December 2014 to March 2018. Therapeutic outcomes and procedure-related complications were analysed.ResultsA total of 41 patients (mean age 67.4 years, 21 male) underwent colorectal ESD. The distribution of the lesions was as follows: rectum (n = 9), sigmoid colon (n = 8), descending colon (n = 6), splenic flexure (n = 1), transverse colon (n = 5), ascending colon (n = 8) and caecum (n = 4). The mean size was 23 (range 12-50) mm. En bloc resection was achieved in 35 (85.4%) out of 41 patients, and R0 resection or clear resection margins was achieved in 33 (94.3%) of the en bloc resection patients. The lesion was upstaged in 14 (34.1%) patients after ESD. Colonic perforation occurred in 3 (7.3%) patients during ESD and was successfully treated with endoscopic clips. There was no procedure-related bleeding. No patient required surgery for management of complications. The median duration of hospitalisation was 1 (range 0-7) day. Four patients with lesions that were upstaged after ESD, from high-grade dysplasia to intramucosal carcinoma with deep submucosal invasion, were referred for colectomy.ConclusionOur early outcome data was comparable to that from large published series. ESD is an effective and feasible treatment for colorectal lesions.Copyright: © Singapore Medical Association.

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