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- Allison Bethanne Reiss, Amy D Glass, Thomas Wisniewski, Benjamin Wolozin, Irving H Gomolin, Aaron Pinkhasov, Joshua De Leon, and Mark M Stecker.
- Medicine, NYU Long Island School of Medicine and NYU Winthrop Hospital, Mineola, New York, USA Allison.Reiss@NYULangone.org.
- J. Investig. Med. 2020 Aug 1; 68 (6): 1135-1140.
AbstractAlzheimer's disease (AD) is a neurodegenerative brain disorder associated with relentlessly progressive cognitive impairment and memory loss. AD pathology proceeds for decades before cognitive deficits become clinically apparent, opening a window for preventative therapy. Imbalance of clearance and buildup of amyloid β and phosphorylated tau proteins in the central nervous system is believed to contribute to AD pathogenesis. However, multiple clinical trials of treatments aimed at averting accumulation of these proteins have yielded little success, and there is still no disease-modifying intervention. Here, we discuss current knowledge of AD pathology and treatment with an emphasis on emerging biomarkers and treatment strategies.© American Federation for Medical Research 2020. No commercial re-use. See rights and permissions. Published by BMJ.
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