• Jhansi R Raju and David V Weinberg.
• Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois 60611, USA.
• Am. J. Ophthalmol. 2002 Apr 1; 133 (4): 564-6.

PurposeTo assess the accuracy and precision of methods in clinical use for intraocular drug injection.DesignExperimental laboratory investigation.MethodsA total of 800 injections were performed using 20 different 1-ml syringes at intended volumes of 0.10 ml and 0.05 ml. The volume of each injection was calculated from mass of water delivered onto an analytic balance.ResultsThe mean measured volume delivered was less than the intended volume for every syringe (P <.001 for each syringe at each volume). A total of 7% and 22% of injections differed by 20% or more from the intended volumes of 0.10 ml and 0.05 ml, respectively. Overdelivery of volume was uncommon.ConclusionClinically relevant materials and methods used for intraocular injection of drugs systematically underdelivered the intended volume.

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