• Muscle & nerve · Feb 2013

    Volume matters: the influence of different botulinum toxin-A dilutions for sialorrhea in amyotrophic lateral sclerosis.

    • Evangelos Anagnostou, Anagnostou Evangelos, Michael Rentzos, Rentzos Michael, Theodoros Alexakis, Alexakis Theodoros, Vasiliki Zouvelou, Zouvelou Vasiliki, Thomas Zambelis, Zambelis Thomas, Ioannis Evdokimidis, and Evdokimidis Ioannis.
    • Department of Neurology, University of Athens, Eginition Hospital, Vas. Sophias Avenue 74, 11528 Athens, Greece. granavan@yahoo.com
    • Muscle Nerve. 2013 Feb 1; 47 (2): 276-8.

    IntroductionWe aimed to determine the effect of different botulinum toxin-A (BTX-A) dilutions on the treatment efficacy and side effects for amyotrophic lateral sclerosis (ALS) related sialorrhea.MethodsTen patients were enrolled in the study. BTX-A dilution for Group A was 100 U in 1 ml of saline, whereas the dilution for Group B was 100 U in 2 ml of saline. Both groups received 20 U of BTX-A in each parotid gland, and assessments were made by means of the Drooling Impact Scale, items 1 and 3 of the ALS functional rating scale, and visual analog scales for drooling and swallowing function.ResultsAlthough both groups exhibited a similar improvement in drooling, Group B had a mild but significant deterioration in bulbar function that was not evident in Group A.ConclusionsThese results suggest that BTX-A has a safer profile when reconstituted with 1 ml instead of 2 ml of saline.Copyright © 2012 Wiley Periodicals, Inc.

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