• Internal medicine · Dec 2020

    Case Reports

    Synchronously Multiple Gastric Adenocarcinomas with Intestinal Mucin Phenotype in a Patient not Infected with Helicobacter Pylori, Showing a Gastritis-like Appearance.

    • Kenichi Kishimoto, Kotaro Shibagaki, Ayako Itawaki, Shinsaku Tanaka, Yusuke Takahashi, Yumi Cho, Yukihiro Ikuta, Naoki Oshima, Makoto Nagasaki, and Shunji Ishihara.
    • Department of Gastroenterology, Faculty of Medicine, Shimane University, Japan.
    • Intern. Med. 2020 Dec 15; 59 (24): 3155-3159.

    AbstractHelicobacter pylori (H. pylori)-negative gastric cancer (HPNGC) usually shows a gastric mucin phenotype, but there are a few case reports of HPNGC with an intestinal mucin phenotype. We herein report a case of multiple HPNGC with an intestinal mucin phenotype showing a gastritis-like appearance. A 68-year-old H. pylori-uninfected man was suspected of having antral gastritis on endoscopy, but a histologic examination revealed multiple well-differentiated adenocarcinomas with positive-CDX2/MUC2/CD10 and negative-MUC5AC/MUC6. P53 was overexpressed, and intestinal metaplasia was sporadically detected in the non-atrophic mucosal background, thus indicating H. pylori-unrelated multistage carcinogenesis. The neoplastic surfaces were covered by a non-neoplastic epithelium, which caused a gastritis-like appearance. This report suggested the possibility of overlooking this neoplasm.

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