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Randomized Controlled Trial Clinical Trial
Ambulatory Treatment of Fast Breathing in Young Infants Aged <60 Days: A Double-Blind, Randomized, Placebo-Controlled Equivalence Trial in Low-Income Settlements of Karachi.
- Shiyam S Tikmani, Amber A Muhammad, Yasir Shafiq, Saima Shah, Naresh Kumar, Imran Ahmed, Iqbal Azam, Omrana Pasha, and Anita K M Zaidi.
- Departments of Paediatrics and Child Health, shiyam.sunder@aku.edu.
- Clin. Infect. Dis. 2017 Jan 15; 64 (2): 184-189.
(See the Editorial Commentary by Jehan and Qazi on pages 190-1) BackgroundIntegrated Management of Childhood Illness recommends that young infants with isolated fast breathing be referred to a hospital for antibiotic treatment, which is often impractical in resource-limited settings. Additionally, antibiotics may be unnecessary for physiologic tachypnea in otherwise well newborns. We tested the hypothesis that ambulatory treatment with oral amoxicillin for 7 days was equivalent (similarity margin of 3%) to placebo in young infants with isolated fast breathing in primary care settings where hospital referral is often unfeasible.© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
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