• Mina Park, Yong Eun Chung, Hye Sun Lee, Jin-Young Choi, Mi-Suk Park, Myeong-Jin Kim, and Ki Whang Kim.
• From the *Department of Radiology, Research Institute of Radiological Science, and †Biostatistics Collaboration Unit, Medical Research Center, College of Medicine, Yonsei University, Seoul, South Korea.
• Invest Radiol. 2014 Apr 1; 49 (4): 195-200.

ObjectivesThe objectives of the study were to evaluate the image quality and diagnostic performance of sinogram-affirmed iterative reconstruction (SAFIRE) for detecting hepatic metastasis and to estimate the potential radiation dose reduction at abdominal computed tomography (CT).Materials And MethodsFifty-nine consecutive patients (mean age, 59.2 years; range, 42-81 years) who had hepatic metastasis and who underwent dual-source abdominal CT were enrolled in this study. The image noise of the liver was compared between full-dose filtered back projection images (FD-FBP) and simulated half-dose images, which used only single-source projection data, and reconstructed with different strengths of SAFIRE (HD-SAFIRE(1-5)) by 1-way analysis of variance with Bonferroni correction. The diagnostic performance for hepatic metastasis was compared by logistic regression with the weighted least squares method and noninferiority test between the FD-FBP images and the half-dose sinogram-affirmed iterative reconstruction (HD-SAFIRE) images.ResultsAs the SAFIRE strength increased, image noise decreased (P < 0.001). The images of HD-SAFIRE(2) showed similar image noise for liver parenchyma (13.4 Hounsfield unit [HU]), signal-to-noise ratio for liver parenchyma (9.2), and lesion-to-liver contrast-to-noise ratio (4.5), compared with the FD-FBP images (12.6 HU, P = 0.668; 9.6, P > 0.999; and 4.5, P > 0.999, respectively). The diagnostic accuracy for hepatic metastasis with the HD-SAFIRE(2) images (87.5%) was not different from that of the FD-FBP images (87.5%, P > 0.999). The diagnostic performance of the HD-SAFIRE(2) images was also noninferior to that of the FD-FBP images (95% confidence interval lower limit difference [-9.16%] excluding the -10% clinical noninferiority limit). The mean (SD) volume CT dose index of FD-FBP was 11.26 (2.66) mGy, and the mean (SD) radiation dose equivalent associated with HD-SAFIRE was estimated to be 5.63 (1.33) mGy.ConclusionsBy applying SAFIRE2, the radiation dose could be reduced by up to 50% compared with the standard-of-care abdominal CT protocol without increasing image noise and without deteriorating diagnostic performance for the detection of hepatic metastasis.

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