• Läkartidningen · Apr 2020

    [ACE2 and coronavirus - a question of balance and dynamics?]

    • Annika Lundström and Per Sandén.
    • med dr, biträdande överläkare, VO neurologi, Danderyds sjukhus; institutionen för kliniska vetenskaper, Danderyds sjukhus, Karolinska institutet.
    • Lakartidningen. 2020 Apr 17; 117.

    AbstractThe new SARS-CoV-2 virus enters cells via angiotensin-converting enzyme 2 (ACE2). ACE2 counteracts ACE and angiotensin II in the renin-angiotensin-aldosterone system (RAAS) and has critical functions in the lung and cardiovascular system. SARS-CoV was found to down-regulate ACE2, leaving angiotensin II unbalanced in affected organs.  A similar effect of SARS-CoV-2 could partly explain risk factors and symptoms, and could potentially be treatable.

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