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J. Gerontol. A Biol. Sci. Med. Sci. · Oct 2010
ReviewMechanisms of vascular aging: new perspectives.
- Zoltan Ungvari, Gabor Kaley, Rafael de Cabo, William E Sonntag, and Anna Csiszar.
- Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA. zoltan-ungvari@ouhsc.edu
- J. Gerontol. A Biol. Sci. Med. Sci. 2010 Oct 1; 65 (10): 1028-41.
AbstractThis review focuses on molecular, cellular, and functional changes that occur in the vasculature during aging; explores the links between mitochondrial oxidative stress, inflammation, and development of vascular disease in the elderly patients; and provides a landscape of molecular mechanisms involved in cellular oxidative stress resistance, which could be targeted for the prevention or amelioration of unsuccessful vascular aging. Practical interventions for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the effects of anti-inflammatory treatments, regular exercise, dietary interventions, and caloric restriction mimetics.
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