• Int. J. Infect. Dis. · Nov 2019

    Efficacy of ventriculoperitoneal shunting in patients with cryptococcal meningitis with intracranial hypertension.

    • Ying Liu, Xiaohua Peng, Weizhen Weng, Jianyun Zhu, Hong Cao, and Shibin Xie.
    • Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: liuy35@mail.sysu.edu.cn.
    • Int. J. Infect. Dis. 2019 Nov 1; 88: 102-109.

    BackgroundVentriculoperitoneal (VP) shunting in cryptococcal meningitis (CM) patients with high intracranial pressure (ICP) has been studied extensively.MethodsA total of 74 CM patients with ICP were identified, including 27 patients with or without ventriculomegaly receiving VP shunting.ResultsThrough retrospective analysis, there was an obvious decline in ICP as well as Cryptococcus count after VP shunting. Damage to the cranial nerves was improved after the surgery. For those patients receiving VP shunting, there was an obvious decline in ICP as well as Cryptococcus count, with less usage of mannitol. Hydrocephalus or ventriculomegaly was improved, and both the clearance time of Cryptococcus and the hospitalization time were shortened (p<0.05). The complications of VP shunting were not common.ConclusionsFor patients diagnosed with CM and with apparent ICP, VP shunting can be considered regardless of whether there is damage to the cranial nerves or hydrocephaly.Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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