• Jeremy J O Turner.
• Department of Diabetes & Endocrinology, Norfolk and Norwich University Hospital; Norwich Medical School; NIHR CRN:Eastern Research Network, Norwich, UK. jeremy.turner@nnuh.nhs.uk.
• Clin Med (Lond). 2017 Jun 1; 17 (3): 270273270-273.

AbstractHypercalcaemia is a common disorder normally caused by primary hyperparathyroidism (PHPT) or malignancy. A proportion of cases present as an emergency, which carries a significant mortality. Emergency management of hypercalcaemia is based on intravenous rehydration with normal saline but when this is inadequate, bisphosphonate therapy is used; more recently the novel anti-resorbtive agent denosumab has been shown to have a useful role in treatment. It is estimated that up to 10% of all cases of PHPT presenting under the age of 45 years have an underlying genetic predisposition; nine potentially causative genes are now recognised and may be screened in routine clinical practice. Although parathyroidectomy is the only curative treatment for PHPT, this is indicated in a minority of cases. Many cases can be adequately managed conservatively and guidance from the 4th international workshop on the management of asymptomatic PHPT has recently been updated in a consensus statement.© Royal College of Physicians 2017. All rights reserved.

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