• Burns · Mar 2021

    Italian recommendations on enzymatic debridement in burn surgery.

    • Rosario Ranno, Michelangelo Vestita, Giulio Maggio, Pasquale Verrienti, Davide Melandri, Catuscia Orlandi, Giuseppe Perniciaro, Armando De Angelis, Roberto D'Alessio, Ilaria Mataro, Eliana Pagnozzi, Giovanni Alessandro, Edoardo Caleffi, Antonio Di Lonardo, Serena Ciappi, Paolo Palombo, Maria Alma Posadinu, Maurizio Stella, Mariarosa Romeo, Jasminka Minic, Maurizio Governa, and Giuseppe Giudice.
    • Burn Unit, Ospedale Cannizzaro, Catania, Italy.
    • Burns. 2021 Mar 1; 47 (2): 408-416.

    IntroductionNexobrid®, a bromelain-based type of enzymatic debridement, has become more prevalent in recent years. We present the recommendations on enzymatic debridement (Nexobrid®)'s role based on the practice knowledge of expert Italian users.MethodsThe Italian recommendations, endorsed by SIUST (Italian Society of Burn Surgery), on using enzymatic debridement to remove eschars for burn treatment were defined. The definition followed a process to evaluate the level of agreement (a measure of consensus) among selected experts, representing Italian burn centers, concerning defined clinical aspects of enzymatic debridement. The consensus involved a multi-phase process based on the Delphi method.ResultsThe consensus panel included experts from Italy with a combined experience of 1068 burn patients treated with enzymatic debridement. At the end of round 3 of the Delphi method, the panel reached 100% consensus on 26 out of 27 statements. The panel achieved full, strong consensus (all respondents strongly agreed on the statement) on 24 out of 27 statements.DiscussionThe statements provided by the Italian consensus panel represent a "ready to use" set of recommendations for enzymatic debridement in burn surgery that both draw from and complete the existing scientific literature on the topic. These recommendations are specific to the Italian experience and are neither static nor definitive. As such, they will be updated periodically as further quality evidence becomes available.Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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