• Internal medicine · Dec 2020

    Case Reports

    Nephrotic Syndrome with Focal Segmental Glomerulosclerosis Induced by Intravitreal Injections of Vascular Endothelial Growth Factor Inhibitor.

    • Kota Kakeshita, Tsutomu Koike, Teruhiko Imamura, Sayaka Murai, Hayato Fujioka, Hidenori Yamazaki, and Koichiro Kinugawa.
    • The Second Department of Internal Medicine, University of Toyama, Japan.
    • Intern. Med. 2020 Dec 1; 59 (23): 3051-3054.

    AbstractAn 83-year-old woman with a 1-year history of scheduled intravitreal injection of vascular endothelial growth factor (VEGF) inhibitor (aflibercept) was diagnosed with nephrotic syndrome due to focal segmental glomerulosclerosis with histopathological findings of segmental infiltration of foam cells in the glomerular capillaries. Her nephrotic syndrome improved immediately following the termination of aflibercept intravitreal injection without steroid therapy. Although widely used to treat ophthalmic diseases, we should keep in mind that even intravitreal injection of VEGF inhibitor, as opposed to systemic administration, can cause kidney injury.

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