• Percin Pazarci, Halil Kaplan, Davut Alptekin, Mehmet Yilmaz, Umit Lüleyap, Ergin Singirik, Aykut Pelit, Halil Kasap, and Arash Yegani.
• Percin Pazarci, Department of Medical Biology, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey, percinpazarci@gmail.com.
• Croat. Med. J. 2020 Feb 29; 61 (1): 55-61.

AimTo determine how daylight exposure in mice affects melatonin protein expression in blood and Kiss1 gene expression in the hypothalamus. The second aim was to assess the relationship between skin cancer formation, daylight exposure, melatonin blood level, and kisspeptin gene expression level.MethodsNew-born mice (n=96) were assigned into the blind group or daylight group. The blind group was raised in the dark and the daylight group was raised under 12 hours light/12 hours dark cycle for 17 weeks. At the end of the 11th week, melanoma cell line was inoculated to mice, and tumor growth was observed for 6 weeks. At the end of the experiment, melatonin level was measured from blood serum and Kiss1 expression from the hypothalamus.ResultsThe blind group had significantly higher melatonin and lower Kiss1 expression levels than the daylight group. Tumor volume was inversely proportional to melatonin levels and directly proportional to Kiss1 expression levels. Tumor growth speed was lower in the blind than in the daylight group.ConclusionMelatonin and Kiss1 were shown to be nvolved in tumor suppression. They were affected by daylight and were mutually affected by each other.

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