• Am. J. Med. · Aug 2020

    Case Reports

    Beware Ketoacidosis with SGLT2 Inhibitors in Latent Autoimmune Diabetes of the Adult.

    • Brendan J Nolan, Suresh Varadarajan, Spiros Fourlanos, and Sandra L Neoh.
    • Department of Endocrinology, Northern Hospital, Epping, Victoria, Australia; Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia. Electronic address: brendanjames.nolan@austin.org.au.
    • Am. J. Med. 2020 Aug 1; 133 (8): e422e424e422-e424.

    BackgroundSodium-glucose co-transporter-2 (SGLT2) inhibitors are increasingly used for the treatment of type 2 diabetes, but have been associated with ketoacidosis.Methods/ResultsWe report a case series of three patients with latent autoimmune diabetes of the adult who presented with ketoacidosis, including one case with normal blood glucose levels, in the context of SGLT2 inhibitor use.ConclusionsSodium-glucose co-transporter-2 inhibitors should be used with caution and close clinical monitoring in patients with latent autoimmune diabetes of the adult. A clinical risk score permits targeted autoantibody testing and should be undertaken prior to commencement of SGLT2 inhibitors or cessation of insulin.Crown Copyright © 2020. Published by Elsevier Inc. All rights reserved.

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