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- Liyuan Yan, Minghan Wang, Jingjing Chen, Xin Zhao, and Haipeng Wang.
- Department of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
- Medicine (Baltimore). 2020 Jul 31; 99 (31): e21612e21612.
BackgroundEmerging evidence indicates the role of gut microbiota in the development of cardiovascular diseases. Thus, gut microbiota is increasingly recognized as a potential therapeutic target of cardiovascular disease. However, the effects of gut microbiome-targeted therapies on cardiometabolic outcomes in children and adolescents remain unclear.MethodsWe plan to perform a systematic search from PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science. Two authors will independently select the relevant studies and extract data according to a previously defined data extraction sheet. We will use the Stata 14.0 statistical software and RevMan V.5.3 software to conduct data analyses.Results And ConclusionThe results of this study will be published in a peer-reviewed journal and provide more evidence for the application of gut microbiome-targeted therapies in children and adolescents for the intervention of cardiovascular risk factors in clinical practice.Protocol Registration NumberINPLASY202060050.
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