• J. Investig. Med. · Dec 2019

    Optimal glucocorticoid dose and the effects on mortality, length of stay, and readmission rates in patients diagnosed with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

    • Asim Kichloo, Michael Aljadah, Navya Vipparla, and Farah Wani.
    • Department of Internal Medicine, Central Michigan University, Saginaw, Michigan, USA kichlooasim@gmail.com.
    • J. Investig. Med. 2019 Dec 1; 67 (8): 1161-1164.

    AbstractThe burden of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is staggering on a national and global level. Yet, surprisingly, there is a profound lack of treatment standardization with glucocorticoids in the treatment of AECOPD. In this review, we bring attention to specific literature that use a cut-off of 60 mg prednisone equivalent per day when distinguishing between high-dose and low-dose glucocorticoid treatment. We hope this review encourages future research to begin incrementally lowering the cut-off dose of 60 mg to discover if mortality, length of hospital stays, and readmission rates change between high-dose and low-dose glucocorticoid treatment. The final hope would be to establish an optimal glucocorticoid dose to treat AECOPD and eliminate treatment ambiguity.© American Federation for Medical Research 2019. No commercial re-use. See rights and permissions. Published by BMJ.

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