• Masashi Saito, Kiyotaka Asanuma, Waku Hatta, Tomoyuki Koike, Tatsuo Hata, Fumiyoshi Fujishima, Toru Furukawa, Michiaki Unno, and Atsushi Masamune.
• Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.
• Intern. Med. 2020 Dec 1; 59 (23): 3001-3007.

AbstractA 38-year-old Japanese man who had been diagnosed with appendiceal carcinoid and undergone ileocecal resection 8 years before presented with duodenal obstruction caused by a submucosal tumor-like appearance. He was diagnosed with long-term recurrence of appendiceal goblet cell carcinoid (GCC) with a multi-morphological pattern based on the histological assessment of a duodenal biopsy and his previously resected appendix. He underwent subtotal stomach-preserving pancreaticoduodenectomy combined with resection of an ileo-colic anastomotic lesion. The GCC recurred at the nearby ileo-colic anastomosis and invaded the duodenum. This late recurrence might have resulted from the unique features of his GCC, which contained cells with different degrees of malignancy.

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