• F Frutos-Vivar, A Esteban, A Anzueto, C Apezteguia, M González, G Bugedo, G D'Empaire, F Palizas, J Elizalde, L Soto, C M David, C Rodrigo, and International Study Mechanical Ventilation Group.
• Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Madrid, España. ffrutos@ucigetafe.com
• Med Intensiva. 2006 Mar 1; 30 (2): 52-61.

ObjectiveTo determine the variables associated with prognosis for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in mechanically ventilated patients.DesignProspective cohort study with retrospective analysis.Location361 Intensive Care Units (ICU) in 20 countries.Patients And MethodsThere were included in the study 522 patients who required mechanical ventilation for more than 12 hours due to an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). In order to determine those variables associated with mortality, there was performed a recursive partition analysis in which the following variables were included: demographics, arterial blood gas prior to intubation, complications arising during mechanical ventilation (barotrauma, acute respiratory distress syndrome, ventilator-associated pneumonia, sepsis), organ dysfunction (cardiovascular, renal, liver, coagulation) and duration of ventilatory support.InterventionsNone. VARIABLES OF PRIME IMPORTANCE: ICU mortality.ResultsICU and hospital mortality rates were 22% and 30%, respectively. Variables associated with mortality were cardiovascular dysfunction, renal dysfunction and duration of ventilatory support > 18 days. Median durations were as follows: mechanical ventilatory support, 4 days (P25: 2, P75: 6); weaning from ventilatory support, 2 days (P25: 1, P75: 5); stay in intensive care unit, 8 days (P25: 5, P75: 13); stay in hospital, 17 days (P25: 10, P75: 27).ConclusionsMortality in the studied cohort of patients with AECOPD was associated with cardiovascular dysfunction, renal dysfunction and prolonged mechanical support.

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