• Qiongshuai Zhang, Fang Cao, Guangcheng Ji, Xiaohong Xu, Yihan Sun, Jiannan Li, Xun Qi, Shaoqian Sun, Yufeng Wang, and Bailin Song.
• Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun.
• Medicine (Baltimore). 2020 Jul 24; 99 (30): e20979e20979.

BackgroundSince the outbreak of Novel Coronavirus Pneumonia (NCP), it has swept the world with rapid development. Up to now, there is no effective drug to treat it. Lianhua Qingwen has been used in the treatment of COVID-19 in China, but there is no systematic review about it. This study will systematically evaluate its efficacy and safety in the treatment of COVID-19.MethodsWe will search electronic database of PubMed, EMBASE, Cochrane library, Web of Science (WOS), China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Chinese Scientific and Journal Database (VIP) and Wan Fang database (Wanfang) for the literature of RCTs of Lianhua Qingwen capsule for coronavirus disease 2019 (COVID-19). We will also search the Chinese Clinical Trial Registry (ChiCTR) and ClinicalTrials.gov (www.ClinicalTrials.gov) for ongoing trials with unpublished data, and the Conference abstracts will be searched manually. We will use the Cochrane Handbook for Systematic Reviews of Interventions to assess the risk of bias. The protocol will be conducted according to the approach and Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P).ResultsThe study results will provide evidence of the efficacy and safety of Lianhua Qingwen (LHQW) for coronavirus disease 2019 (COVID-19).ConclusionThe result of the study will be published in a peer-reviewed journal.Prospero Registration NumberCRD42020180877.

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