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- Ayaka Machida, Takashi Funaki, Koji Nishida, Ryu-Ichiro Imai, Yoko Nakaoka, Shu-Ichi Seki, Yu-Ichi Baba, Toru Kubo, Naohito Yamasaki, Hiroaki Kitaoka, Sho-Ichi Kubokawa, Hiroshi Sakaeda, Kazuya Kawai, Naohisa Hamashige, and Yoshinori Doi.
- Department of Medicine, Chikamori Hospital, Japan.
- Intern. Med. 2020 Dec 15; 59 (24): 317731813177-3181.
AbstractAlthough cardiovascular involvement is a well-known complication correlated with a poor prognosis in patients with systemic sclerosis, there are few reports on valvular heart disease. Forty patients with systemic sclerosis were retrospectively analyzed. Valvular heart disease was found in six patients, five of whom had severe tri-leaflet aortic stenosis. Three of these 5 patients were ≤71 years old. Two frail elderly patients who underwent transcatheter aortic valve replacement died within two years. Premature-onset aortic stenosis is not uncommon in patients with systemic sclerosis. When considering mechanical intervention, the evaluation of frailty is important.
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