• Jean-Christophe Orban, Audrey Scarlatti, Pierre-Eric Danin, Jean Dellamonica, Gilles Bernardin, and Carole Ichai.
• Réanimation Médico-Chirurgicale, Hôpital Saint-Roch, Nice University Hospital, 06000 Nice, France. Electronic address: orban.jc@chu-nice.fr.
• J Crit Care. 2015 Dec 1; 30 (6): 1184-9.

PurposePathophysiology of cardiac arrest corresponds to an ischemia-reperfusion syndrome with deep impairment of microcirculation. Muscular tissue oxygen saturation (StO2) is a noninvasive method of evaluation of microcirculation. Our study was aimed at assessing the prognosis value of muscular StO2 in patients admitted for out-of-hospital cardiac arrest (OHCA) and treated with hypothermia.Materials And MethodsWe conducted a prospective bicentric observational study including OHCA patients treated with therapeutic hypothermia. Baseline StO2, derived variables (desaturation and resaturation slopes), and lactate levels were compared at different times between patients with good and poor outcomes. Prognosis was assessed by the Cerebral Performance Category (CPC) score at 6 months after admission (CPC 1-2, good outcome; CPC 3-5, poor outcome).ResultsForty-four patients were included, 17 good and 27 poor outcomes at 6 months. At admission, StO2 and lactate levels were lower in good outcome patients. Desaturation and resaturation slopes did not differ between groups.ConclusionsAfter an OHCA treated with therapeutic hypothermia, StO2 was correlated with outcome. Further research is needed to better understand the pathophysiological process underlying our results.Copyright © 2015 Elsevier Inc. All rights reserved.

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