• Cèlia Sintas, Jèssica Fernández-Morales, Marta Vila-Pueyo, Bernat Narberhaus, Concepció Arenas, Patricia Pozo-Rosich, Alfons Macaya, and Bru Cormand.
• Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain Center for Biomedical Network Research on Rare Diseases (CIBERER)-Institute of Health Carlos III, Spain.
• Cephalalgia. 2015 Aug 1; 35 (9): 776-82.

BackgroundMigraine is a common disabling condition that affects approximately 15% of the population. Several genome-wide association studies have attempted to identify susceptibility variants involved in migraine, reporting several candidate loci for the disorder.MethodsIn order to replicate findings from previous genome-wide association studies, a case-control association study was performed. Twelve single nucleotide polymorphisms were genotyped in a Spanish sample of 512 migraine with aura patients and 535 migraine-free controls.ResultsNominal associations were found for single nucleotide polymorphisms rs2651899 (within the PRDM16 gene), rs10166942 (near TRPM8), rs12134493 (close to TSPAN2) and rs10504861 (near MMP16) in our migraine with aura sample.ConclusionsOur study provides suggestive replication, in a Spanish migraine with aura sample, of four genome-wide association study findings previously reported in common migraine. However, larger sample sets should be explored to confirm our results.© International Headache Society 2014.

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