• Sara Y Tartof, Lei Qian, Vennis Hong, Rong Wei, Ron F Nadjafi, Heidi Fischer, Zhuoxin Li, Sally F Shaw, Susan L Caparosa, Claudia L Nau, Tanmai Saxena, Gunter K Rieg, Bradley K Ackerson, Adam L Sharp, Jacek Skarbinski, Tej K Naik, and Sameer B Murali.
• Kaiser Permanente Southern California, Pasadena, California (S.Y.T., L.Q., V.H., R.W., H.F., Z.L., S.F.S., S.L.C., C.L.N.).
• Ann. Intern. Med. 2020 Nov 17; 173 (10): 773-781.

BackgroundObesity, race/ethnicity, and other correlated characteristics have emerged as high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)-associated outcomes, yet studies have not adequately disentangled their effects.ObjectiveTo determine the adjusted effect of body mass index (BMI), associated comorbidities, time, neighborhood-level sociodemographic factors, and other factors on risk for death due to COVID-19.DesignRetrospective cohort study.SettingKaiser Permanente Southern California, a large integrated health care organization.PatientsKaiser Permanente Southern California members diagnosed with COVID-19 from 13 February to 2 May 2020.MeasurementsMultivariable Poisson regression estimated the adjusted effect of BMI and other factors on risk for death at 21 days; models were also stratified by age and sex.ResultsAmong 6916 patients with COVID-19, there was a J-shaped association between BMI and risk for death, even after adjustment for obesity-related comorbidities. Compared with patients with a BMI of 18.5 to 24 kg/m2, those with BMIs of 40 to 44 kg/m2 and greater than 45 kg/m2 had relative risks of 2.68 (95% CI, 1.43 to 5.04) and 4.18 (CI, 2.12 to 8.26), respectively. This risk was most striking among those aged 60 years or younger and men. Increased risk for death associated with Black or Latino race/ethnicity or other sociodemographic characteristics was not detected.LimitationDeaths occurring outside a health care setting and not captured in membership files may have been missed.ConclusionObesity plays a profound role in risk for death from COVID-19, particularly in male patients and younger populations. Our capitated system with more equalized health care access may explain the absence of effect of racial/ethnic and socioeconomic disparities on death. Our data highlight the leading role of severe obesity over correlated risk factors, providing a target for early intervention.Primary Funding SourceRoche-Genentech.

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