• Laura Ruggeri, Claudia Cariello, Maurizio Stefani, and Rubia Baldassarri.
• Cardiothoracic Anaesthesia and Intensive Care Medicine, Cardiothoracic Department, University Hospital of Pisa, Pisa, Italy. fabiodoc64@hotmail.com
• J. Cardiothorac. Vasc. Anesth.. 2011 Jun 1;25(3):437-43.

ObjectiveTo describe the anesthetic management of transcatheter aortic valve implantation (TAVI) with the transaxillary approach.DesignAn observational cohort study.SettingTwo university hospitals.ParticipantsTwenty-two patients with severe aortic stenosis (± regurgitation) at high risk for surgical valve replacement, with contraindications for transfemoral TAVI (81 ± 4.9 years; logistic EuroSCORE, 27% ± 16.9%).InterventionGeneral anesthesia or local anesthesia plus sedation followed by postoperative care.Measurements And Main ResultsLocal anesthesia plus sedation and general anesthesia were used in 14 and 8 patients, respectively. Two patients undergoing local anesthesia were monitored with transesophageal echocardiography and supported with noninvasive mask ventilation during the procedure. Main complications included hemodynamic instability requiring inotropes (2 patients), severe postimplant aortic regurgitation requiring immediate second valve-in-valve implantation (1 patient), valve embolization requiring open-valve surgery (1 patient), subclavian artery dissection compromising the flow to a mammary artery graft (1 patient), ascending aortic dissection (1 patient), stroke (2 patients), and atrioventricular block requiring pacemaker implantation (3 patients). Four patients experienced an increased (baseline value × 1.5) postoperative serum creatinine. Five patients required red blood cell tranfusions (2 units). Intensive care unit stay and hospital stay were 6 (4-23) hours and 8 (8-9) days, respectively. All patients were alive 30 days after the procedure. The 6-month mortality was 9%.ConclusionsTransaxillary TAVI is feasible in high-risk patients with aortic stenosis and peripheral vasculopathy. Nevertheless, severe procedural complications are possible, and anesthesiologists should be prepared to assist in the management of these conditions.Copyright © 2011 Elsevier Inc. All rights reserved.

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