• Tiansheng Wang, Neal Benedict, Keith M Olsen, Rong Luan, Xi Zhu, Ningning Zhou, Huilin Tang, Yingying Yan, Yao Peng, and Luwen Shi.
• Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, China. Electronic address: tiansheng@bjmu.edu.cn.
• J Crit Care. 2015 Oct 1; 30 (5): 1101-6.

AbstractPharmacists are integral members of the multidisciplinary team for critically ill patients. Multiple nonrandomized controlled studies have evaluated the outcomes of pharmacist interventions in the intensive care unit (ICU). This systematic review focuses on controlled clinical trials evaluating the effect of pharmacist intervention on medication errors (MEs) in ICU settings. Two independent reviewers searched Medline, Embase, and Cochrane databases. The inclusion criteria were nonrandomized controlled studies that evaluated the effect of pharmacist services vs no intervention on ME rates in ICU settings. Four studies were included in the meta-analysis. Results suggest that pharmacist intervention has no significant contribution to reducing general MEs, although pharmacist intervention may significantly reduce preventable adverse drug events and prescribing errors. This meta-analysis highlights the need for high-quality studies to examine the effect of the critical care pharmacist.Copyright © 2015 Elsevier Inc. All rights reserved.

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