• Medicina clinica · Jul 2019

    Review

    Allogeneic stem cell transplantation in the era of novel therapies for acute lymphoblastic leukaemia.

    • Pere Barba and Izaskun Elorza.
    • Servicio de Hematología, Hospital Universitario Vall d'Hebron-Universitat Autónoma de Barcelona, Barcelona, España. Electronic address: pbarba@vhio.net.
    • Med Clin (Barc). 2019 Jul 5; 153 (1): 28-34.

    AbstractImmunotherapy is changing the treatment of acute lymphoblastic leukaemia (ALL) in adults and children. However, regardless of these new therapies, allogeneic hematopoietic cell transplantation (allo-HCT) still play a key role in the treatment of ALL, although it is uncertain how these new therapies will impact on the transplant procedure and indications. This article reviews the indications of allo-HCT for children and adults diagnosed with ALL, the different sources and conditioning regimens for transplantation as well as the role of measurable residual diseases pre- and post-HCT in the era of the new therapies for ALL.Copyright © 2019 Elsevier España, S.L.U. All rights reserved.

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