• Reg Anesth Pain Med · Oct 2020

    Use of three-dimensional printing of a lumbar skeletal model for intrathecal administration of nusinersen: a brief technical report.

    • Hiroaki Abe, Reo Inoue, Rikuhei Tsuchida, Kenji Azuma, Kenji Ino, Mitsuru Konishi, Jun Hozumi, and Masahiko Sumitani.
    • Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Bunkyo-ku, Japan.
    • Reg Anesth Pain Med. 2020 Oct 1; 45 (10): 757-760.

    AbstractSpinal muscular atrophy (SMA) is an autosomal recessive hereditary neurodegenerative disease causing progressive muscle atrophy, weakness and kyphoscoliosis. Nusinersen is a therapeutic agent for SMA that should be administered intrathecally. However, due to severe kyphoscoliosis, lumbar puncture can be challenging. Here, we present our experience of intrathecal administration of nusinersen in an SMA patient with severe kyphoscoliosis using a life-size three-dimensional printing (3D) skeletal model created with 3D printer. With this strategy, we were able to rapidly and safely perform the lumbar puncture.© American Society of Regional Anesthesia & Pain Medicine 2020. No commercial re-use. See rights and permissions. Published by BMJ.

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