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Multicenter Study
Health-related quality of life of bosutinib (SKI-606) in imatinib-resistant or imatinib-intolerant chronic phase chronic myeloid leukemia.
- Peter C Trask, David Cella, Nadine Besson, Virginia Kelly, Tamás Masszi, and Dong-Wook Kim.
- Pfizer Inc., Groton, CT, USA. peter.trask@sanofi.com
- Leuk. Res. 2012 Apr 1; 36 (4): 438-42.
AbstractUnderstanding the impact of second-line tyrosine kinase inhibitor therapy on the health-related quality of life (HRQOL) of imatinib (IM)-resistant and IM-intolerant chronic phase chronic myeloid leukemia (CP CML) patients is important given the increased survival that comes with therapy. As part of a bosutinib single-arm phase 2 trial, 200 IM-resistant and 88 IM-intolerant CP CML patients' HRQOL was assessed prior to and throughout treatment with the Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu). Little HRQOL impairment was demonstrated at baseline. Over the course of 96 weeks on bosutinib therapy, patients noted statistically significant and/or clinically meaningful improvements on several FACT-Leu scales.Copyright © 2011 Elsevier Ltd. All rights reserved.
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