• Nicole Varble, Vincent M Tutino, Jihnhee Yu, Ashish Sonig, Adnan H Siddiqui, Jason M Davies, and Hui Meng.
• From the Department of Mechanical and Aerospace Engineering (N.V., H.M.), Toshiba Stroke and Vascular Research Center (N.V., A.H.S., J.M.D., H.M.), Department of Biomedical Engineering (V.M.T., H.M.), Department of Biostatistics (J.Y.), Department of Neurosurgery (A.S., A.H.S., J.M.D., H.M.), Department of Radiology (A.H.S.), Jacobs Institute (A.H.S., J.M.D.), Gates Vascular Institute/Kaleida Health (A.H.S., J.M.D.), Department of Biomedical Informatics (J.M.D.), University at Buffalo, State University of New York.
• Stroke. 2018 Apr 1; 49 (4): 856-864.

Background And PurposeMany ruptured intracranial aneurysms (IAs) are small. Clinical presentations suggest that small and large IAs could have different phenotypes. It is unknown if small and large IAs have different characteristics that discriminate rupture.MethodsWe analyzed morphological, hemodynamic, and clinical parameters of 413 retrospectively collected IAs (training cohort; 102 ruptured IAs). Hierarchal cluster analysis was performed to determine a size cutoff to dichotomize the IA population into small and large IAs. We applied multivariate logistic regression to build rupture discrimination models for small IAs, large IAs, and an aggregation of all IAs. We validated the ability of these 3 models to predict rupture status in a second, independently collected cohort of 129 IAs (testing cohort; 14 ruptured IAs).ResultsHierarchal cluster analysis in the training cohort confirmed that small and large IAs are best separated at 5 mm based on morphological and hemodynamic features (area under the curve=0.81). For small IAs (<5 mm), the resulting rupture discrimination model included undulation index, oscillatory shear index, previous subarachnoid hemorrhage, and absence of multiple IAs (area under the curve=0.84; 95% confidence interval, 0.78-0.88), whereas for large IAs (≥5 mm), the model included undulation index, low wall shear stress, previous subarachnoid hemorrhage, and IA location (area under the curve=0.87; 95% confidence interval, 0.82-0.93). The model for the aggregated training cohort retained all the parameters in the size-dichotomized models. Results in the testing cohort showed that the size-dichotomized rupture discrimination model had higher sensitivity (64% versus 29%) and accuracy (77% versus 74%), marginally higher area under the curve (0.75; 95% confidence interval, 0.61-0.88 versus 0.67; 95% confidence interval, 0.52-0.82), and similar specificity (78% versus 80%) compared with the aggregate-based model.ConclusionsSmall (<5 mm) and large (≥5 mm) IAs have different hemodynamic and clinical, but not morphological, rupture discriminants. Size-dichotomized rupture discrimination models performed better than the aggregate model.© 2018 American Heart Association, Inc.

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