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Case Reports
Small changes in calcium replacement therapy triggering hypercalcaemia and rising creatinine - a case series.
- Luis Loureiro Harrison, Alison Crooks, Michael Kelly, Fiona Green, and Thalakunte Muniraju.
- Registrar in Renal Medicine, Queen Elizabeth University Hospital, UK.
- Scot Med J. 2020 Feb 1; 65 (1): 32-37.
AbstractIn this article, we present four cases of renal failure secondary to hypercalcaemia which were brought to the attention of our hospital's nephrology team. These happened in the setting of simple medication changes for hypoparathyroidism post-thyroid surgery. These cases have in common minor changes in preparations leading to significant adverse events. In two cases, excipient changes were the only changes identified in the patients' regimen. In all cases, cessation of the offending calcium preparation and treatment with IV rehydration led to a return to baseline creatinine levels. Communicating to patients the importance of consistency in how calcium and vitamin D supplements are taken is crucial in preventing adverse effects. Prescribers should be aware of excipient changes and that these are not always clinically insignificant.
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