• Shenghui Zhou, Xiaoli Liu, Xiaoxia Wang, Fenglin Xi, Xiaoke Luo, Liang Yao, and Hao Tang.
• College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region.
• Medicine (Baltimore). 2019 Jul 1; 98 (30): e16446e16446.

BackgroundThe global prevalence of Irritable bowel syndrome (IBS) is estimated to be as high as 15% and a number of different non-pharmacological and pharmacological treatments have been used to manage IBS in clinical practice, which poses great challenges for clinicians to make appropriate decisions. Hence, a systematic review and network meta-analysis on all available pharmacological and non-pharmacological treatments for IBS is needed to provide reliable evidence.MethodsWe will search the Cochrane Central Register of Controlled Trials (CENTRAL), the Cochrane IBD Group Specialized Trials Register, MEDLINE, EMBASE, and Chinese Biomedical medicine (CBM) from inception to 31, May 2019. Randomized controlled trials of pharmacological and nonpharmacological interventions for IBS will be included. Study quality will be assessed on the basis of the methodology and categories described in the Cochrane Collaboration Handbook. Primary outcomes are global or clinical improvement and quality of life. A Bayesian network meta-analysis would be performed, and relative ranking of agents would be assessed. A node splitting method will be used to examine the inconsistency between direct and indirect comparisons when a loop connecting 3 arms exists.ResultsResearchers will rank the effectiveness and safety of the potentials interventions for IBS according the characteristics of patients by conducting an advanced network meta-analysis based on Bayesian statistical model, and interpret the results by using GRADE approach.ConclusionThe conclusion of our study will provide updated evidence to rank the effectiveness and safety of pharmacological and non-pharmacological interventions for IBS.Ethics And DisseminationEthical approval is not applicable since this study is a network meta-analysis based on published trials.Protocol Registration NumberCRD42018083844.

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