• Thiago Domingos Corrêa, Matos Gustavo Faissol Janot de GFJ http://orcid.org/0000-0001-9996-7040 Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., Bravim Bruno de Arruda BA http://orcid.org/0000-0001-8290-8554 Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., Ricardo Luiz Cordioli, Garrido Alejandra Del Pilar Gallardo ADPG http://orcid.org/0000-0002-2469-185X Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., Assuncao Murillo Santucci Cesar de MSC http://orcid.org/0000-0002-0741-4869 Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., Barbas Carmen Silvia Valente CSV http://orcid.org/0000-0002-3922-6256 Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., Karina Tavares Timenetsky, Roseny Dos Reis Rodrigues, Hélio Penna Guimarães, Rabello Filho Roberto R http://orcid.org/0000-0001-7018-224X Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., Lomar Frederico Polito FP http://orcid.org/0000-0002-7856-0716 Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., Farah Christina de La Cruz Scarin, Carla Luciana Batista, Adriano José Pereira, Guerra João Carlos de Campos JCC http://orcid.org/0000-0002-4156-529X Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., Bárbara Vieira Carneiro, Ricardo Kenji Nawa, Rodrigo Martins Brandão, Antônio Eduardo Pereira Pesaro, Moacyr Silva Júnior, Fabricio Rodrigues Torres de Carvalho, Silva Cilene Saghabi de Medeiros CSM http://orcid.org/0000-0003-3544-6646 Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., Ana Claudia Ferraz de Almeida, Marcelo Franken, Marcele Liliane Pesavento, Eid Raquel Afonso Caserta RAC http://orcid.org/0000-0002-8241-3241 Hospital Israelita Albert Einstein , São Paulo , SP , Brazil ., and Leonardo José Rolim Ferraz.
• Hospital Israelita Albert Einstein , São Paulo , SP , Brazil .
• Einstein (Sao Paulo). 2020 Jan 1; 18: eAE5793.

AbstractIn December 2019, a series of patients with severe pneumonia were identified in Wuhan, Hubei province, China, who progressed to severe acute respiratory syndrome and acute respiratory distress syndrome. Subsequently, COVID-19 was attributed to a new betacoronavirus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Approximately 20% of patients diagnosed as COVID-19 develop severe forms of the disease, including acute hypoxemic respiratory failure, severe acute respiratory syndrome, acute respiratory distress syndrome and acute renal failure and require intensive care. There is no randomized controlled clinical trial addressing potential therapies for patients with confirmed COVID-19 infection at the time of publishing these treatment recommendations. Therefore, these recommendations are based predominantly on the opinion of experts (level C of recommendation).

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