• Anesthesiology clinics · Sep 2020

    Review

    Using Electroencephalography (EEG) to Guide Propofol and Sevoflurane Dosing in Pediatric Anesthesia.

    • Ian Yuan, Ting Xu, and Charles Dean Kurth.
    • Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Perelman School of Medicine, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address: YUANI@EMAIL.CHOP.EDU.
    • Anesthesiol Clin. 2020 Sep 1; 38 (3): 709-725.

    AbstractSevoflurane and propofol-based anesthetics are dosed according to vital signs, movement, and expired sevoflurane concentrations, which do not assess the anesthetic state of the brain and, therefore, risk underdose and overdose. Electroencephalography (EEG) measures cortical brain activity and can assess hypnotic depth, a key component of the anesthetic state. Application of sevoflurane and propofol pharmacology along with EEG parameters can more precisely guide dosing to achieve the desired anesthetic state for an individual pediatric patient. This article reviews the principles underlying EEG use for sevoflurane and propofol dosing in pediatric anesthesia and offers case examples to illustrate their use in individual patients.Copyright © 2020 Elsevier Inc. All rights reserved.

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