• Gac Med Mex · Jan 2020

    Cutaneous susceptibility to SARS-CoV-2 infection according to the expression of viral entry factors in the skin.

    • Myriam Garduño-Soto and José A Choreño-Parra.
    • Secretaría de Salud, Hospital General de México "Dr. Eduardo Liceaga", Departamento de Dermatología, Ciudad de México, México.
    • Gac Med Mex. 2020 Jan 1; 156 (4): 354-357.

    IntroductionReports of dermatological manifestations in patients with COVID-19 suggest a possible cutaneous tropism of SARS-CoV-2; however, the capacity of this virus to infect the skin is unknown.ObjectiveTo determine the susceptibility of the skin to SARS-CoV-2 infection based on the expression of viral entry factors ACE2 and TMPRSS2 in this organ.MethodA comprehensive analysis of human tissue gene expression databases was carried out looking for the presence of the ACE2 and TMPRSS2 genes in the skin. mRNA expression of these genes in skin-derived human cell lines was also assessed.ResultsThe analyses showed high co-expression of ACE2 and TMPRSS2 in the gastrointestinal tract and kidney, but not in the skin. Only the human immortalized keratinocyte HaCaT cell line expressed detectable levels of ACE2, and no cell line originating in the skin expressed TMPRSS2.ConclusionsOur results suggest that cutaneous manifestations in patients with COVID-19 cannot be directly attributed to the virus. It is possible that cutaneous blood vessels endothelial damage, as well as the effect of circulating inflammatory mediators produced in response to the virus, are the cause of skin involvement.Copyright: © 2020 Permanyer.

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