• Gac Med Mex · Jan 2020

    Review

    The big challenge of SARS-CoV-2 latency: testes as reservoir.

    • Ricardo López-Romero, María de Jesús Nambo-Lucio, Emmanuel Salcedo-Carrillo, María de Los Ángeles Hernández-Cueto, and Mauricio Salcedo-Vargas.
    • Centro Médico Nacional Siglo XXI, Hospital de Oncología, Ciudad de México, México.
    • Gac Med Mex. 2020 Jan 1; 156 (4): 328-333.

    AbstractIn the efforts to explain COVID-19 pathophysiology, studies are being carried out on the correspondence between the expression of SARS-CoV-2 cell receptors and viral sequences. ACE2, CD147 and TMPRSS2 receptors expression could indicate poorly explored potential infection targets. For the genomic analysis of SARS-CoV-2 receptors, using BioGPS information was decided, which is a portal that centralizes genetic annotation resources, in combination with that of The Human Protein Atlas, the largest portal of human transcriptome and proteome data. We also reviewed the most recent articles on the subject. RNA and viral receptor proteins expression was observed in numerous anatomical sites, which partially coincides with the information reported in the literature. High expression in testicular cells markedly stood out, and it would be therefore important ruling out whether this anatomical site is a SARS-CoV-2 reservoir; otherwise, germ cell damage, as it is observed in infections with other RNA viruses, should be determined.Copyright: © 2020 Permanyer.

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