• Gac Med Mex · Jan 2020

    Comparative Study

    Design, manufacture and initial tests of a drug-eluting coronary stent.

    • Arturo Abundes-Velasco, Jorge Padilla-Ibarra, Gian M Jiménez-Rodríguez, Julio I Farjat-Pasos, Eduardo A Arias-Sánchez, Félix Damas-de Los Santos, Marco A Martínez-Ríos, Francisco J Molina-Méndez, Tomás E Sánchez-Pérez, Marco M Arai-Ito, Sebastián Aceves-Díaz González, David A Rodríguez-Parra, Alberto Aranda-Fraustro, Felipe A Masso-Rojas, Ramsés Galaz-Méndez, and Marco A Peña-Duque.
    • Instituto Nacional de Cardiología "Ignacio Chávez", Desarrollo e Innovación Tecnológica, Ciudad de México, México.
    • Gac Med Mex. 2020 Jan 1; 156 (4): 279-285.

    IntroductionA drug-eluting coronary stent is being developed at the National Institute of Cardiology of Mexico for the treatment of ischemic heart disease.ObjectiveTo establish the best animal model for the tests, to show the advances in the drug-eluting stent prototype, to assess two drugs' antiproliferative activity and histological results.MethodSmooth muscle cell culture tests were performed in order to assess sirolimus and paclitaxel antiproliferative properties. The drugs were encapsulated inside the polymeric matrix of the stents. Rabbits and pigs were used as animal models.ResultsSirolimus and paclitaxel showed an inhibitory effect, which was higher for the latter. Infrared spectroscopy and light and optical microscopy showed that the drug/polymer layer properly adhered to the stent. At a four-week follow-up, both animal models showed satisfactory clinical evolution and adequate histological response, although the porcine model was shown to be more suitable for future protocols.ConclusionsPreliminary tests of the drug-eluting stent provided bases for the development of a study protocol with an adequate number of pigs and with clinical angiographic and histopathological three-month follow-up.Copyright: © 2020 Permanyer.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…