• Norvell Perezbusta-Lara, Rocío Tirado-Mendoza, and Javier R Ambrosio-Hernández.
• Universidad Nacional Autónoma de México, Facultad de Medicina, Departamento de Microbiología y Parasitología, Ciudad de México, México.
• Gac Med Mex. 2020 Jan 1; 156 (4): 265-272.

IntroductionAcute respiratory infections are the second cause of mortality in children younger than five years, with 150.7 million episodes per year. Human orthopneumovirus (hOPV) and metapneumovirus (hMPV) are the first and second causes of bronchiolitis; type 2 human orthorubulavirus (hORUV) has been associated with pneumonia in immunocompromised patients.ObjectiveTo define hOPV, hMPV and hORUV geographical distribution and circulation patterns.MethodAn observational, prospective cross-sectional pilot study was carried out. Two-hundred viral strains obtained from pediatric patients were genotyped by endpoint reverse transcription polymerase chain reaction (RT-PCR).ResultsOne-hundred and eighty-six positive samples were typed: 84 hOPV, 43 hMPV, two hORUV and 57 co-infection specimens. Geographical distribution was plotted. hMPV, hOPV, and hORUV cumulative incidences were 0.215, 0.42, and 0.01, respectively. Cumulative incidence of hMPV-hORUV and hMPV-hOPV coinfection was 0.015 and 0.23; for hOPV-hMPV-hORUV, 0.035; and for hORUV-hOPV, 0.005. The largest number of positive cases of circulating or co-circulating viruses occurred between January and March.ConclusionsThis study successfully identified circulation and geographical distribution patterns of the different viruses, as well as of viral co-infections.Copyright: © 2020 Permanyer.

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