• Zaira Romero-López, Fermín Alejandro Rojas-Cisneros, María Dolores Ochoa-Vázquez, Favio Gerardo Rico-Méndez, and José Antonio Mata-Marín.
• Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital General, Departamento de Neumología, Ciudad de México, México.
• Gac Med Mex. 2020 Jan 1; 156 (4): 286-293.

IntroductionChronic obstructive pulmonary disease (COPD) is the most prevalent respiratory problem in the world. Patients with human immunodeficiency virus (HIV) infection have a higher prevalence of smoking and recurrent lung infections and are at higher risk of COPD.ObjectiveTo determine the prevalence of COPD in HIV-diagnosed patients referred to an infectious diseases hospital.MethodIndividuals with HIV infection without previous or ongoing antiretroviral treatment, with chronic respiratory symptoms, with or without a history of exposure for the development of COPD were included. Pre- and post-bronchodilation spirometry, high-resolution computed tomography, viral load determination and CD4 count were carried out. Spirometry measurements were compared with Wilcoxon's test.ResultsSixty-six HIV-diagnosed patients, with a mean age of 31.5 years were included; 64 were males and two females. The prevalence of COPD was 7.6 %. The group with obstruction had a lower CD4 count (27.3 versus 225.9) and higher viral load (165,000 versus 57,722), in comparison with the group without obstruction. A positive correlation was observed between lower viral load and higher forced expiratory volume in 1 second/forced vital capacity ratio.ConclusionHIV-positive patients with a lower CD4 count and a higher viral load show a decrease in spirometry values.Copyright: © 2020 Permanyer.

29 keywords...

hide…