• Biochem. Biophys. Res. Commun. · Aug 1989

    Chromium (V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium (VI).

    • X L Shi and N S Dalal.
    • Department of Chemistry, West Virginia University Morgantown 26506.
    • Biochem. Biophys. Res. Commun. 1989 Aug 30; 163 (1): 627-34.

    AbstractElectron spin resonance measurements provide evidence for the formation of long-lived Cr(V) intermediates in the reduction of Cr(VI) by glutathione reductase in the presence of NADPH and for the hydroxyl radical formation during the glutathione reductase catalyzed reduction of Cr(VI). Hydrogen peroxide suppresses Cr(V) and enhances the formation of hydroxyl radicals. Thus Cr(V) intermediates catalyze generation of hydroxyl radicals from hydrogen peroxide through a Fenton-like reaction. Thus the mechanism of Cr(VI) toxicity might involve the interaction between macromolecules and the hydroxyl radicals.

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