• Drug Discov Ther · Jan 2020

    Treat 2019 novel coronavirus (COVID-19) with IL-6 inhibitor: Are we already that far?

    • Yuanyuan Zhang, Yanyan Zhong, Lin Pan, and Jing Dong.
    • Department of Rheumatology and Clinical Immunology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
    • Drug Discov Ther. 2020 Jan 1; 14 (2): 100-102.

    AbstractThe world is in the midst of the coronavirus disease 2019 (COVID-19) pandemic. Interleukin 6 (IL-6) inhibitor (tocilizumab) had been suggested for the treatment of acute respiratory distress syndrome (ARDS) patients based on the concept of "cytokine storm" in COVID-19. However, we still lack reliable studies to verify "cytokine storm" in COVID-19 pneumonia. Furthermore, IL-6 inhibitor has potential hazards of inducing infectious diseases. The efficacy of IL-6 monoclonal antibody-directed therapy remains to be fully evaluated.

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