• Gina Gheorghe, Simona Bungău, Gabriela Ceobanu, Mădălina Ilie, Nicolae Bacalbaşa, Ovidiu Gabriel Bratu, Cosmin Mihai Vesa, Mihnea-Alexandru Găman, and Camelia Cristina Diaconu.
• Department of Gastroenterology, University of Medicine and Pharmacy "Carol Davila", 050474 Bucharest, Romania. Electronic address: gheorghe_gina2000@yahoo.com.
• J Formos Med Assoc. 2021 Feb 1; 120 (2): 794-803.

AbstractHepatic disease accounts for approximately 2 million deaths/year worldwide. Liver fibrosis, as the last stage of numerous chronic liver diseases, is one of the most relevant prognostic factors. The liver biopsy with the histopathological examination is considered to be the "gold standard" for the identification and staging of the hepatic fibrosis. However, liver biopsy is known as an invasive investigation that has multiple limitations. Research studies conducted in the last few years focused on identifying non-invasive type methods for the evaluation of hepatic fibrosis; usually, there are 2 categories of such investigations: serologic tests and imaging techniques. This narrative review presents the non-invasive investigation methods used in the liver fibrosis evaluation. New molecular perspectives on fibrogenesis and fibrosis regression, as well as the appearance of therapeutic antifibrotic agents, justify the necessity of non-invasive tools to detect and grade liver fibrosis.Copyright © 2020 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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